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We have shown previously that a fetal sheep liver extract (FSLE) containing significant quantities of fetal ovine gamma globin chain (Hbγ) and LPS injected into aged (>20 months) mice could reverse the altered polarization (increased IL-4 and IL-10 with decreased IL-2 and IFNγ) in cytokine production seen from ConA stimulated lymphoid cells of those mice. The mechanism(s) behind this change in...
Previous reports from our group have established that the fetal ovine gamma globin chain (Hbγ) and LPS can synergize in the induction of pro-inflammatory cytokines, especially TNFα, from mouse and human leukocytes. A fetal sheep liver extract (FSLE) which was observed to have marked immunoregulatory properties in vivo and in vitro had independently been observed to contain significant amounts of each...
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