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This study was carried out with the aim to optimize the pharmacological profile of gliquidone (GLI)-a poorly bioavailable hypoglycaemic agent sparingly soluble in water- through complexation with cyclodextrins. In order to increase the apparent solubility of GLI, two cyclodextrins, namely β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD), were tested. The effect of cyclodextrin addition...
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