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The dissociation constant and some thermodynamic parameters of synthesized pyrazolo[5,1-b]quinazolines are determined by Calvin Bjerrum pH titration method in mixed organic-water (60:40v/v) solvent systems. The evaluated data are discussed in terms of the electron donating or electron withdrawing nature of side chain substitutions. The compound containing 4-flouro group is the most acidic whereas...
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