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For the analysis of mucosal immunity to HIV-1, we have recently established a line of transgenic (Tg) mice expressing the TCRα and TCRβ genes of the murine CTL clone RT1 specific for P18-I10 (RGPGRAFVTI), an immunodominant gp160 envelope-derived epitope of IIIB isolate, restricted by the H-2D d MHC-I molecule. Here we examine those cells bearing specific TCR among the intraepithelial lymphocytes...
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