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Vaccination during pregnancy is increasingly being used as an effective approach for protecting both young infants and their mothers from serious infections. Drawing conclusions from published studies in this area can be difficult because of the inability to compare vaccine trial results across different studies and settings due to the heterogeneity in the definitions of terms used to assess the safety...
Sense and avoid is the primary technical hurdle to unmanned aircraft system airspace integration. Several sense and avoid system concepts have been proposed, including numerous system architectures and technologies for aircraft surveillance, and threat detection and resolution. However, there is little evidence to support concept refinement, evaluation, requirements development, and validation. This...
The Division of Microbiology and Infectious Diseases at the National Institute of Allergy and Infectious Diseases, National Institutes of Health organized a series of conferences, entitled “Enrolling Pregnant Women in Clinical Trials of Vaccines and Therapeutics”, to discuss study design and the assessment of safety in clinical trials conducted in pregnant women. A panel of experts was charged with...
In immunization safety research, individuals are considered at risk for the development of certain adverse events following immunization (AEFI) within a specific period of time referred to as the risk interval. These intervals should ideally be determined based on biologic plausibility considering features of the AEFI, presumed or known pathologic mechanism, and the vaccine. Misspecification of the...
This paper presents an integrated robust and resilient control strategy to enhance the operational safety and performance of nuclear power plants. The objective of robust control is to minimize the sensitivity of plant operations to exogenous disturbances and internal faults while achieving a guaranteed level of performance with a priori specified bounds of uncertainties. On the other hand, the role...
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