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Although both uveal (UM) and cutaneous (CM) melanoma cells derive from the transformed melanocytes, their biology varies significantly in several aspects. Malignant transformation is frequently associated with alternations in cell glycosylation, in particular those concerning branched complex-type N-glycans. These changes occur principally in β1,4-N-acetylglucosaminyltransferase III (GnT-III) that...
We have examined the diversity between primary uveal (92‐1 and Mel202) and cutaneous (FM55P and IGR‐39) melanoma cells in their interaction with vitronectin, and established the effect of integrins and β1,6‐branched N‐oligosaccharides on this process. The adhesion level of uveal melanoma cells to vitronectin was at least twice lower than that of cutaneous ones, but all cells tested repaired scratch...
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