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Drug toxicity is a long‐standing concern of modern medicine. A typical anti‐pain/fever drug paracetamol often causes hepatotoxicity due to peroxynitrite ONOO−. Conventional blood tests fail to offer real‐time unambiguous visualization of such hepatotoxicity in vivo. Here we report a luminescent approach to evaluate acute hepatotoxicity in vivo by chromophore‐conjugated upconversion nanoparticles....
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