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Background: In the rat, two forms of the pancreatic secretory trypsin inhibitor, PSTI-I and PSTI-II, are secreted into pancreatic juice. It is assumed that their role is to protect the pancreas from premature activation of the proteaserich pancreatic juice. In the small intestine, PSTI-I, also called ‘monitor peptide’, is thought to have a different role: PSTI-I competes with protein for activated...
Background: Recent genetic investigations into cationic trypsinogen and pancreatic secretory trypsin inhibitor (PSTI) led to the conclusion that mutations in either gene can contribute to the development of (hereditary) chronic pancreatitis. Since genetic animal models are not available yet, we have studied the Wistar-Bonn/ Kobori (WBN/Kob) rat, a model for chronic pancreatitis (CP). To explore the...
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