The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Organ Procurement and Transplant Network (OPTN) policy currently requires the testing of all potential organ donors for human T‐cell lymphotrophic virus (HTLV)‐1/2. Most Organ Procurement Organizations (OPO) use the Abbott HTLV‐I/HTLV‐II Enzyme Immunoassay (EIA). This assay will no longer be manufactured after December 31, 2009; the only commercially available FDA‐licensed assay will be the Abbott PRISM HTLV‐I/II assay which poses many challenges to OPO use for organ donor screening. As a result, screening donors for HTLV‐1/2 in a timely manner pretransplant after December 31, 2009 will be challenging. The true incidence of HTLV‐1 in United States (U.S.) organ donors is not well described but appears to be low (∼0.03–0.5%). HTLV‐1 is associated with malignancy and neurological disease; HTLV‐2 has not been convincingly associated with disease in humans. Donors that are HTLV‐1/2 seropositive are infrequently used despite most results being either false positive or resulting from HTLV‐2 infection. There is urgent need to encourage the development of assays, instruments and platforms optimized for organ donors that can be used to screen for transmissible disease in donors; these must have appropriate sensitivity and specificity to identify all infections while minimizing organ loss through false positive testing....
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.