The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Background
The vitamin A derivative all‐trans retinoic acid (RA) regulates early stages of inner ear development. As the early disruption of the RA pathway results in profound mispatterning of the developing inner ear, this confounds analyses of specific roles in later stages. Therefore, we used the temporal‐specific exposure of all‐trans RA or diethylaminobenzaldehyde to evaluate RA functions in...
The vertebrate inner ear is a labyrinthine sensory organ responsible for perceiving sound and body motion. While a great deal of research has been invested in understanding the auditory system, a growing body of work has begun to delineate the complex developmental program behind the apparatuses of the inner ear involved with vestibular function. These animal studies have helped identify genes involved...
Ocular coloboma is a congenital disorder of the eye where a gap exists in the inferior retina, lens, iris, or optic nerve tissue. With a prevalence of 2–19 per 100,000 live births, coloboma, and microphthalmia, an associated ocular disorder, represent up to 10% of childhood blindness. It manifests due to the failure of choroid fissure closure during eye development, and it is a part of a spectrum...
Confocal images of hindbrain neurons in two‐day old wild type (left) and tshz3b mRNA‐injected (right) zebrafish embryos. The two top panels show the GFP‐positive branchiomotor neurons (green) of Tg(isl1:GFP) embryos co‐stained with the zn‐5 antibody against Alcam a (red). The bottom two panels highlight the hindbrain reticulospinal neurons as visualized using the rmo44 α‐Neurofilament‐medium antibody...
In flies, the zinc‐finger protein Teashirt promotes trunk segmental identities, in part, by repressing the expression and function of anterior hox paralog group (PG) 1–4 genes that specify head fates. Anterior‐posterior patterning of the vertebrate hindbrain also requires Hox PG 1–4 function, but the role of vertebrate teashirt‐related genes in this process has not been investigated. In this work,...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.