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In article number 1806957, Weiyue Lu, Zhen Gu, and co‐workers engineer a dual bioresponsive drug‐delivery depot that can respond to the acidic pH and reactive oxygen species within the tumor microenvironment for co‐delivery of anti‐PD1 antibody and an epigenetic modulator. This combination therapy increases the immunogenicity of cancer cells and enhances the antitumor immune response. The pond represents...
Patients with advanced melanoma that is of low tumor‐associated antigen (TAA) expression often respond poorly to PD‐1/PD‐L1 blockade therapy. Epigenetic modulators, such as hypomethylation agents (HMAs), can enhance the antitumor immune response by inducing TAA expression. Here, a dual bioresponsive gel depot that can respond to the acidic pH and reactive oxygen species (ROS) within the tumor microenvironment...
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