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Over the past two decades, metalloproteinases (MMPs), including MMP‑2, MMP‑3, and MMP‑9, have been implicated as important players in mechanisms underlying various forms of neuroplasticity. In particular, MMP‑3 was found to be involved in both cognitive functions and in plasticity phenomena, but the underlying molecular mechanisms remain largely elusive. In general, it is believed that functional...
It is well established that matrix metalloproteinases (MMPs) play an important role in mechanisms of excit‑ atory plasticity, learning, and memory, especially those dependent on hippocampus. Recently, we have demon‑ strated that MMP-9, but not MMP-3, is involved in spike timing-dependent plasticity in mouse barrel cortex, and that MMP-3 supports NMDA-dependent LTP in the hip‑ pocampus. However, the...
The morphometrical and volumetrical changes of the middle cerebral artery (MCA) during the fetal period of development were analyzed by digital-image analysis system (DIAS). Examinations were performed on 304 MCAs from 152 brains of human fetuses ranging from the 12th to 40th weeks of gestation. MCAs were analyzed with respect to its branching from the internal carotid artery and its division into...
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