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The existence of interleukin (IL)-2 has been recognized for over 25 years, and it remains one of the most extensively studied cytokines. Here we present a broad overview of IL-2 history, functional activities, biological sources, regulation and applications to disease treatment. IL-2 exerts a wide spectrum of effects on the immune system, and it plays crucial roles in regulating both immune activation...
Interleukin 2 (IL-2) mediated signalling results from ligand binding and subsequent hetero-dimerization of IL-2rβ and γc. The high-affinity IL-2 receptor (IL-2r) is a heterotrimer comprised of the IL-2rα, IL-2rβ and γc subunits. Whereas human IL-2 effectively binds to either human or murine lymphocytes, murine IL-2 binds with markedly higher affinity to murine receptor complexes than to human complexes...
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