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Background and aims
Pioglitazone (PIO), a potent agonist of PPAR‐gamma, is a promising candidate treatment for cocaine use disorder (CUD). We tested the effects of PIO on targeted mechanisms relevant to CUD: cocaine craving and brain white matter (WM) integrity. Feasibility, medication compliance and tolerability were evaluated.
Design
Two‐arm double‐blind randomized controlled proof‐of‐concept...
Background and aims
Alcohol use is a major contributor to injuries, mortality and the burden of disease. This review updates knowledge on risk relations between dimensions of alcohol use and health outcomes to be used in global and national Comparative Risk Assessments (CRAs).
Methods
Systematic review of reviews and meta‐analyses on alcohol consumption and health outcomes attributable to alcohol...
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