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The anticonvulsive potential of classical antiepileptics co-administered with β-adrenergic receptor antagonists against generalized tonic–clonic seizures was evaluated in the model of maximal electroshock (MES)-induced convulsions. Propranolol, acebutolol, metoprolol and atenolol were tested in the doses not affecting the electroconvulsive threshold. Propranolol and metoprolol lowered the ED 50...
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