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Kisspeptins, a family of peptide products derived from the KiSS-1 gene, activate their cognate receptor GPR54 in various target tissues to exert disparate functions, including inhibition of tumor metastasis and control of reproductive function. In contrast to the plethora of studies that have analyzed in recent years the regulatory functions of the KiSS-1/GPR54 system, only a limited number of reports...
The UII and urotensin II-related peptide (URP) genes belong to the same superfamily as the somatostatin gene. It has been previously shown that somatostatin activates the UII-receptor (UTR). In contrast, the possible interaction between UII and URP and somatostatin receptors has remained scarcely analyzed. Herein, we have investigated the effects of UII and URP on cell proliferation and free cytosolic...
Azay, J., C. Nagain, M. Llinares, C. Devin, J. A. Fehrentz, N. Bernad, C. Roze and J. Martinez. Comparative study of in vitro and vivo activities of bombesin pseudopeptide analogs modified on the C-terminal dipeptide fragment. Peptides 19(1) 57-63, 1998.-Analogs of bombesin in which the peptide bond between the two last amino acid residues were replaced by a pseudopeptide bond mimicking the transition...
Oxyntomodulin inhibits gastric acid secretion via its C-terminal octapeptide. Its minimal active structure was delineated by testing, on histamine-stimulated gastric acid secretion in the conscious rat, the inhibitory effect of octapeptide analogues, shortened either or both on their N- or <C -terminus. The octapeptide may be simplified by deleting the two C-terminal amino acid while keeping...
The in vivo effects of JMV-320 (a highly selective CCK B receptor ligand) and of CCK-4 on exploratory activity and memory in rats were compared. JMV-320 and CCK-4 did not modulate exploratory activity in an open field test but decreased it in an elevated plus-maze. CCK-4 (50 μg/kg) impaired passive avoidance response 3 h after training and JMV-320 (1 and 10 μg/kg) decreased active avoidance...
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