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INTRODUCTION: Over the last few decades, electromagnetic pollution from generated electromagnetic fields increases. Particularly important from the point of view of our health is the exposure to extremely low frequency electromagnetic fields (ELF‑EMF). ELF‑EMF is derived from many man-made sources, including power transmission lines or transformers. The effects induced by ELF-EMF exposure on biological...
BACKGROUNDANDAIMS: The phenomenon of communication between the nervous and immune systems is commonly accepted. There were postulated several pathways for information exchange between these two systems, among them: neuronal with the vagus nerve, and enzymatic exercised through cyclooxygenases. The fact of biological compensation of many processes in our organisms is well known. In our project we hypothesized...
BACKGROUND AND AIMS: Peripheral administration of gram-negative bacteria endotoxin – lipopolisaccharide (LPS) is known to activate the hypothalamo-pituitary adrenal axis (HPAA) and brain noradrenergic systems. We studied the vagotomized rats responses to peripherally administered LPS using the HPLC-ED to measure the concentration of noradrenaline and their metabolite MHPG in various brain regions...
BACKGROUND AND AIMS: We investigated the number of proliferating cells in the dentate gyrus of the hippocampus and anxietylike behavior of mice after damage to the projections from the locus coeruleus as a result of a single administration (50 mg/kg) of DSP-4 that is a selective neurotoxin of central and peripheral noradrenergic neurons. METHODS: Adult male Swiss mice were divided into 2 groups whose...
BACKGROUND AND AIMS: This interdisciplinary project, linking neurophysiology, neuroendocrinology and psychology, aims to explore biomarkers of stress among rescue personnel under emergency situations (catastrophe) and correlating the results of psychophysical features. We expect that an catastrophe produces significant changes in the concentration of biological indicators of stress that may be related...
Hippocampal formation (HPC) is a limbic structure that generates a synchronized EEG activity, termed the theta rhythm. The theta rhythm is a sinusoidal activity with a frequency band ranging from 3 to 12 Hz. Many years of research conducted with the use of the model of HPC slice preparations allowed to determine the specific role of the cholinergic and GABAergic systems in the production of this EEG...
Alcoholism is a complex disease with hereditary influence. To elucidate genetic contribution, microarrays were used to probe for differences in gene expression in limbic system structures in strains of rats selected for several generations for alcohol preference: Warsaw High Preferring (WHP) strain and Warsaw Low Preferring (WLP) strain. Microarray analyses of medial prefrontal cortex (mPFC), hippocampus...
Orexins are two neuropeptides appearing to be particularly interesting in terms of hippocampal (HPC) EEG development. Recent studies conducted in our laboratory demonstrated that orexin A induce theta oscillations in HPC slices in certain concentrations. The lack of data concerning the influence of orexins on the changes in the activity of other neurotransmission systems encouraged our research. Thus...
The parasitic protozoan Toxoplasma gondii is capable of altering intermediate host natural defensive behavior, which is believed to facilitate the parasite’s transmission in the environment. Despite extensive research on the subject, the exact mechanism behind the host manipulation remains obscure. However, key neurotransmitter levels are listed among possible contributing factors. Thus, the study...
Yohimbine is an indol alkaloid obtained from the root of Rauwolfia serpentina or from the bark of Pausinystalia yohimbe tree. This alkaloid is extensively used to explore the role of alpha 2 – adrenoceptors in experimental and clinical studies. Yohimbine has been predominantly used as a pharmacological tool in treatment of men’s impotence. Moreover, it was proved that yohimbine induces anxiety states...
Social rank means that the individuals take various positions in a social group. The individuals high in the social rank have more social opportunities compared to those low in the hierarchy. Social rank may have important consequences for the hypothalamo-pituitary-adrenocortical (HPA) system activity. It is known that the noradrenergic brain neuronal activity is closely related to the control of...
This discussion panel is aimed to facilitate information exchange and experience sharing between scientists using social interaction (SI) paradigms in their research. It would be unique occasion to gather numerous scholars who are involved in behavioral analysis of SI as well as researches that are thinking about employing such approach. During the discussion we would like to put emphasis on several...
In 1975 Besedovsky’s team as a first reported that hypothalamopituitary-adrenal axis (HPA) can be activated by immune stimuli. In his seminal experiment he noted that plasma corticosterone was elevated after peripheral immune challenges, such as horse and sheep red blood cells. Subsequently very many experimental data has been collected and confirmed his idea. Also many investigators have noted that...
Experimental results clearly indicate the existence of bidirectional communication between the nervous and immune systems. Changes in the activity of immune system produced by infections or any inflammatory event elicit neurochemical, endocrine and behavioral effects. But the details of those relationships are still not clear. It is hypothesized that afferent branches of nervous vagus may participate...
The noradrenergic system of the hypothalamic paraventricular nuclei (PVN) has been associated with feeding, but whether it controls feeding in a way that is relevant to energy balance is still unclear. Rats were maintained on a high energy, carbohydrate-rich diet (HC), or a low energy, carbohydrate-free, protein-rich diet (LP), until their daily energy intakes equalized. When injected with noradrenaline...
The noradrenergic system of the hypothalamic paraventricular nuclei (PVN) has been associated with feeding, but whether it controls feeding in a way that is relevant to energy balance is still unclear. Rats were maintained on a high energy, carbohydrate-rich diet (HC), or a low energy, carbohydrate-free, protein-rich diet (LP), until their daily energy intakes equalized. When injected with noradrenaline...
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