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Deoxynivalenol (DON), one of the most prevalent mycotoxins in the world, and is capable of inducing immune disorders in humans and animals. The aim of this study was to determine the effect of feed contaminated with DON on the number of TLR2- and TLR9-positive cells and their mRNA expression in the porcine large intestine. The experiment was conducted on two equal groups of pigs (n=4). The experimental...
Most plant food products and feed ingredients can be contaminated with small doses of fusarial mycotoxins, which cause subclinical changes in humans and animals. The purpose of this study has been to evaluate the effect of low doses of zearalenone (40 µg/kg BW) and deoxynivalenol (12 µg/kg BW) administered daily per os to gilts on T-lymphocyte subpopulations (CD4⁺CD8⁻,CD4⁺CD8⁺,CD4⁻CD8⁺) in mesenteric...
Mycotoxins are toxic secondary metabolites produced by fungi. Those biologically active compounds occur naturally and they include zearalenone (ZEN), a mycotoxin that contaminates plant material, including the ingredients used in the production of commercial dog food. The influence of monotonic, low-dose and long-term exposure to ZEN on pre-pubertal bitches has not been fully explored to date. This...
If n ≥ 3 and d ∈ {3,4} or if n ≥ 1 and d ≥ 5, then any sequence of d-dimensional cubes of edge lengths not greater than 1 whose total volume does not exceed (n+1)⋅2−dcan be on-line packed into n unit d-dimensional cubes.
The study evaluated the proliferative activity of immunocompetent cells in the jejunal and iliac lymph nodes of prepubertal female wild boars exposed to deoxynivalenol and zearalenone in naturally contaminated feed. The evaluation was performed with the use of the MTT assay and 2 mitogens: lipopoh saccharide (LPS) and concanavalin A. Intensified proliferative processes in T and B lymphocytes were...
The contamination of agricultural crops with Fusarium mycotoxins poses one of the greatest problems in food production. Wild boars live in specific habitats and are physiologically sensitive to Fusarium mycotoxins, therefore, they are an interesting model for studies investigating the effects of the discussed toxin, in particular under low-dose exposure. The objective of this study was to determine...
The aim of this study was to determine whether exposure to low doses of DON leads to changes in serum hematological and biochemical profiles. In the experiment, pre-pubertal gilts (with body weight of up to 25 kg) were administered DON per os at a daily dose of 12 |ig/kg BW (group E, n=18) or a placebo (group C, n=21) over a period of 42 days. Blood for analysis was sampled seven times at weekly intervals...
The objective of the presented study was to examine the influence of Fusarium mycotoxins (zearalenone - ZEN and deoxynivalenol - DON), administered separately and in combination, on the activity of cecal enzymes (ß-glucosidase and ß-glucuronidase) in gilts which were fed fodder contaminated with these mycotoxins. The activity of ß-glucosidase and ß-glucuronidase varied in the range of 0.170-1.236...
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