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Regulation of sizes and shapes of tooth are important matters to consider in generating an entirely bioengineered tooth for future tooth replacement therapy. In our current study, we investigated that whether an extent of contact area between epithelial and mesenchymal cell aggregates, which was reconstituted from embryonic day 14.5 molar tooth germ-derived single cells by our cell manipulation method,...
The regenerative therapy ultimately aims to develop bioengineered organs that can replace lost or damaged organs following disease, injury or aging. Recently, we showed that the artificial organ germ, which generates a structurally correct tooth, could be reconstituted by in vitro cell manipulation (Nature Methods 4, 227-230, 2007). In this study, we revealed that neural crest-like cells, which were...
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