Search results for: Kyung Hwan Kim

Items from 1 to 20 out of 285 results

article

Synergistic Effect of Ferroptosis‐Inducing Nanoparticles and X‐Ray Irradiation Combination Therapy (Small 19/2024)

Chaewon Bae, Rodrigo Hernández Millares, Suhyun Ryu, Hyowon Moon, more

Small > 20 > 19 > n/a - n/a

Cancer Nanomedicine In article number 2310873, Woong Sub Koom, Sung‐Joon Ye, Kangwon Lee, and co‐workers report the strategy and efficacy of tumor combination treatment with X‐ray irradiation and the developed FHA‐nanoparticles that induce ferroptosis. Effective tumor synergistic treatment effects were confirmed, and Monte Carlo simulations were performed to evaluate the physical interactions. This...

article

Synergistic Effect of Ferroptosis‐Inducing Nanoparticles and X‐Ray Irradiation Combination Therapy

Chaewon Bae, Rodrigo Hernández Millares, Suhyun Ryu, Hyowon Moon, more

Small > 20 > 19 > n/a - n/a

Ferroptosis, characterized by the induction of cell death via lipid peroxidation, has been actively studied over the last few years and has shown the potential to improve the efficacy of cancer nanomedicine in an iron‐dependent manner. Radiation therapy, a common treatment method, has limitations as a stand‐alone treatment due to radiation resistance and safety as it affects even normal tissues. Although...

article

Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches

Faheem Ahmed, In Suk Kang, Kyung Hwan Kim, Arun Asif, more

Journal of Medical Virology > 95 > 4 > n/a - n/a

Cancer management is major concern of health organizations and viral cancers account for approximately 15.4% of all known human cancers. Due to large number of patients, efficient treatments for viral cancers are needed. De novo drug discovery is time consuming and expensive process with high failure rate in clinical stages. To address this problem and provide treatments to patients suffering from...

article

Working memory deficits in patients with idiopathic restless legs syndrome are associated with abnormal theta‐band neural synchrony

Kwang Su Cha, Jun‐Sang Sunwoo, Jung‐Ick Byun, Tae‐Joon Kim, more

Journal of Sleep Research > 30 > 5 > n/a - n/a

Cognitive impairment, particularly prefrontal function, has been reported in patients with restless legs syndrome. However, working memory performance in patients with restless legs syndrome remains uncertain. The present study aimed to examine working memory performance in patients with restless legs syndrome by investigating electroencephalography theta‐band oscillations within task‐relevant brain...

article

Comparative analysis of structural valve deterioration after bioprosthetic tricuspid valve replacement: Bovine pericardial versus porcine valves

Yoonjin Kang, Ho Young Hwang, Suk Ho Sohn, Jae Woong Choi, more

Artificial Organs > 45 > 8 > 911 - 918

This study was conducted to compare the occurrence and the risk factors of structural valve deterioration (SVD) after bioprosthetic tricuspid valve replacement (TVR) between bovine pericardial valves and porcine valves. One‐hundred and thirty‐four TVR patients were enrolled; 108 patients underwent TVR with bovine pericardial bioprostheses (BTVR group) and 26 underwent TVR with porcine bioprostheses...

article

Vesical Imaging–Reporting and Data System for Multiparametric MRI to Predict the Presence of Muscle Invasion for Bladder Cancer

Seung Baek Hong, Nam Kyung Lee, Suk Kim, Il Wan Son, more

Journal of Magnetic Resonance Imaging > 52 > 4 > 1249 - 1256

Background The Vesical Imaging–Reporting and Data System (VI‐RADS) is a newly developed system of bladder cancer staging with multiparametric MRI (mpMRI), which can be used to predict the presence of muscle invasion for bladder cancer. Purpose To evaluate the accuracy of three mpMRI series (T₂WI, diffusion‐weighted imaging [DWI], and dynamic contrast‐enhanced image [DCEI]) and VI‐RADS for diagnosing...

article

Is it worth carrying out ultrasound–magnetic resonance imaging fusion targeted biopsy on Prostate Imaging Reporting and Data System score 3 prostate lesions?

Kyung Hwan Kim, Ja Yoon Ku, Won Young Park, Seung Baek Hong, more

International Journal of Urology > 27 > 5 > 431 - 438

Objectives To evaluate the use of ultrasound–magnetic resonance imaging fusion targeted biopsy for Prostate Imaging Reporting and Data System 3 prostate lesions. Methods We identified 227 patients with prostate‐specific antigen levels ≥4 ng/mL who underwent concurrent transrectal ultrasound‐guided systemic biopsy and fusion biopsy. Suspicious prostatic lesions were assessed in accordance with Prostate...

article

4‐1BB Delineates Distinct Activation Status of Exhausted Tumor‐Infiltrating CD8⁺ T Cells in Hepatocellular Carcinoma

Hyung‐Don Kim, Seongyeol Park, Seongju Jeong, Yong Joon Lee, more

Hepatology > 71 > 3 > 955 - 971

Background and Aims Targeting costimulatory receptors with agonistic antibodies is a promising cancer immunotherapy option. We aimed to investigate costimulatory receptor expression, particularly 4‐1BB (CD137 or tumor necrosis factor receptor superfamily member 9), on tumor‐infiltrating CD8⁺ T cells (CD8⁺ tumor‐infiltrating lymphocytes [TILs]) and its association with distinct T‐cell activation features...

article

Mutations in the microRNA172 binding site of SUPERNUMERARY BRACT (SNB) suppress internode elongation in rice

Hyeonso Ji, Chang-deok Han, Gang-Seob Lee, Ki-Hong Jung, more

Rice > 2019 > 12 > 1 > 1-14

Background Internode elongation is an important agronomic trait in rice that determines culm length, which is related to lodging, panicle exsertion, and biomass. sui4 (shortened uppermost internode 4) mutants show reduced internode length and a dwarf phenotype due to shortened internodes; the uppermost internode is particularly severely affected. The present study was performed to identify the molecular...

article

Accumulation of γ-linolenic acid and stearidonic acid in rapeseeds that heterologously express the Phytophthora citrophthora Δ6 desaturase gene

Kyeong-Ryeol Lee, Hami Yu, Inhwa Jeon, Kyung-Hwan Kim, more

Plant Biotechnology Reports > 2019 > 13 > 4 > 399-407

Most oilseeds contain polyunsaturated fatty acids, such as linoleic acid (LA) and α-linolenic acid (ALA) that are important essential fatty acids for human health. γ-Linolenic acid (GLA) and stearidonic acid (SDA), synthesized from LA and ALA by Δ6 desaturase, respectively, are mainly obtained from algae and fish. Given the benefits of GLA and SDA to human health, many researchers have investigated...

article

Maternal and newborn health services utilization in Jimma Zone, Southwest Ethiopia: a community based cross-sectional study

Lelisa Sena Dadi, Melkamu Berhane, Yusuf Ahmed, Esayas Kebede Gudina, more

BMC Pregnancy and Childbirth > 2019 > 19 > 1 > 1-13

Background Majority of causes of maternal and newborn mortalities are preventable. However, poor access to and low utilization of health services remain major barriers to optimum health of the mothers and newborns. The objectives of this study were to assess maternal and newborn health services utilization and factors affecting mothers’ health service utilization. Methods A community based cross-sectional...

article

Numerical Simulation on Thickness Dependency and Bias Stress Test of Ultrathin IGZO Thin‐Film Transistors Via a Solution Process

Mohamed Labed, Nouredine Sengouga, Kyung Hwan Kim, You Seung Rim

physica status solidi (a) > 216 > 7 > n/a - n/a

The authors report the effect of ultra‐thin channel layer thickness on the performance of an amorphous InGaZnO (a‐IGZO) thin‐film transistor (TFT). Numerical simulation is used to investigate the thickness effect on the a‐IGZO TFT output parameters. The simulation results are compared to measurements of the stability of nitrate ligand‐based hexaaqua complexes solution‐processed ultrathin a‐IGZO transistors...

article

High accumulation of γ-linolenic acid and Stearidonic acid in transgenic Perilla (Perilla frutescens var. frutescens) seeds

Kyeong-Ryeol Lee, Kyung-Hwan Kim, Jung Bong Kim, Seung-Bum Hong, more

BMC Plant Biology > 2019 > 19 > 1 > 1-15

Background Polyunsaturated fatty acids such as linoleic acid (LA) and α-linolenic acid (ALA) are abundant in vegetable oils and are important for human health. In the body, LA and ALA are respectively converted to the omega-6 fatty acid γ-linolenic acid (GLA) and the omega-3 fatty acid stearidonic acid (SDA) by Δ6 desaturase (D6DES). Currently, dietary GLA and SDA are mainly obtained from marine organisms,...

article

The influence of histology on the response of brain metastases to gamma knife radiosurgery: a propensity score-matched study

Kyung Hwan Kim, Min Ho Lee, Kyung-Rae Cho, Jung-Won Choi, more

Acta Neurochirurgica > 2018 > 160 > 12 > 2379-2386

Background In terms of response to fractionated radiotherapy, metastatic brain tumors of certain origins are considered radioresistant. Objective To determine the influence of “radioresistant” histology on outcomes of brain metastases treated with radiosurgery. Methods Between 2001 and 2017, 121 patients with brain metastases from renal cell carcinoma (RCC) and 2151 from non-small cell lung cancer...

article

Is Low-Lying Optic Chiasm an Obstacle to an Endoscopic Endonasal Approach for Retrochiasmatic Craniopharyngiomas? (Korean Society of Endoscopic Neurosurgery -003)

Kyung Hwan Kim, Yong Hwy Kim, Yun-Sik Dho, Jung Hee Kim, more

World Neurosurgery > 2018 > 114 > C > e306-e316

Despite advances in endoscopic techniques, retrochiasmatic craniopharyngiomas (CPs) are difficult to remove completely, because the low-lying optic chiasm often provides an obstacle to an endoscopic endonasal approach. This study aimed to identify the endoscopic surgical outcomes of the retrochiasmatic CP and resolve the issues related to low-lying optic chiasm.We reviewed 154 consecutive patients...

article

Rapid deployment or sutureless versus conventional bioprosthetic aortic valve replacement: A meta-analysis

Suk Ho Sohn, Myoung-jin Jang, Ho Young Hwang, Kyung Hwan Kim

The Journal of Thoracic and Cardiovascular Surgery > 2018 > 155 > 6 > 2402-2412.e5

This meta-analysis was conducted to compare the early and follow-up outcomes of aortic valve replacement using rapid deployment or sutureless (RD) valves (RDAVR group) with aortic valve replacement using conventional bioprostheses (CAVR group).A literature search of 5 online databases was conducted. The primary outcomes were postoperative complications and the secondary outcomes included the aortic...

article

Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A

Jihye Kim, Dong-Yeop Chang, Hyun Woong Lee, Hoyoung Lee, more

Immunity > 2018 > 48 > 1 > 161-173.e5

Acute hepatitis A (AHA) involves severe CD8⁺ T cell-mediated liver injury. Here we showed during AHA, CD8⁺ T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8⁺ T cells. TCR-independent activation of non-HAV-specific CD8⁺ T cells were detected in patients, as indicated by...

article

Mapping of a major quantitative trait locus for bakanae disease resistance in rice by genome resequencing

Hyeonso Ji, Tae-Ho Kim, Gang-Seob Lee, Hyun-Ju Kang, more

Molecular Genetics and Genomics > 2018 > 293 > 3 > 579-586

Bakanae disease (BD) has emerged as a serious threat in almost all rice cultivation regions worldwide. Nampyeong is a Korean japonica rice variety known to be resistant to BD. In this study, quantitative trait locus (QTL) mapping was performed with F2 and F3 plants derived from a cross between the Nampyeong variety and a susceptible Korean japonica line, DongjinAD. First, resequencing of Nampyeong...

article

Vegetable oil production in vegetative plant tissues

Kyeong-Ryeol Lee, Eun-Ha Kim, Kyung-Hwan Kim, Jong-Sug Park, more

Plant Biotechnology Reports > 2017 > 11 > 6 > 385-395

Vegetable oils, which are stored in seeds as triacylglycerol (TAG), represent a valuable source of food, fuel, and industrial raw materials. Given the increasing demand for vegetable oils, it is essential to increase vegetable oil production in a sustainable manner. To boost the supply of vegetable oil, strategies to produce oils in the vegetative tissues of biomass crops are being investigated. Producing...

article

Reduced P300 amplitude during a visuospatial attention task in idiopathic rapid eye movement sleep behavior disorder

Jung-Ick Byun, Byeong Uk Lee, Minah Kim, Jun-Sang Sunwoo, more

Sleep Medicine > 2017 > 38 > C > 78-84

Idiopathic rapid eye movement sleep behavior disorder (IRBD) patients are prone to cognitive deficits, which include attention, executive, and visuospatial dysfunctions. Even patients with normal cognition may exhibit subclinical electrophysiological dysfunction. This study aimed to evaluate visuospatial attention processing in IRBD patients with normal cognition and to compare their findings with...

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INFONA - science communication portal

Search results for: Kyung Hwan Kim

Synergistic Effect of Ferroptosis‐Inducing Nanoparticles and X‐Ray Irradiation Combination Therapy (Small 19/2024)

Synergistic Effect of Ferroptosis‐Inducing Nanoparticles and X‐Ray Irradiation Combination Therapy

Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches

Working memory deficits in patients with idiopathic restless legs syndrome are associated with abnormal theta‐band neural synchrony

Comparative analysis of structural valve deterioration after bioprosthetic tricuspid valve replacement: Bovine pericardial versus porcine valves

Vesical Imaging–Reporting and Data System for Multiparametric MRI to Predict the Presence of Muscle Invasion for Bladder Cancer

Is it worth carrying out ultrasound–magnetic resonance imaging fusion targeted biopsy on Prostate Imaging Reporting and Data System score 3 prostate lesions?

4‐1BB Delineates Distinct Activation Status of Exhausted Tumor‐Infiltrating CD8⁺ T Cells in Hepatocellular Carcinoma

Mutations in the microRNA172 binding site of SUPERNUMERARY BRACT (SNB) suppress internode elongation in rice

Accumulation of γ-linolenic acid and stearidonic acid in rapeseeds that heterologously express the Phytophthora citrophthora Δ6 desaturase gene

Maternal and newborn health services utilization in Jimma Zone, Southwest Ethiopia: a community based cross-sectional study

Numerical Simulation on Thickness Dependency and Bias Stress Test of Ultrathin IGZO Thin‐Film Transistors Via a Solution Process

High accumulation of γ-linolenic acid and Stearidonic acid in transgenic Perilla (Perilla frutescens var. frutescens) seeds

The influence of histology on the response of brain metastases to gamma knife radiosurgery: a propensity score-matched study

Is Low-Lying Optic Chiasm an Obstacle to an Endoscopic Endonasal Approach for Retrochiasmatic Craniopharyngiomas? (Korean Society of Endoscopic Neurosurgery -003)

Rapid deployment or sutureless versus conventional bioprosthetic aortic valve replacement: A meta-analysis

Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A

Mapping of a major quantitative trait locus for bakanae disease resistance in rice by genome resequencing

Vegetable oil production in vegetative plant tissues

Reduced P300 amplitude during a visuospatial attention task in idiopathic rapid eye movement sleep behavior disorder

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