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Carbon monoxide (CO), a byproduct of heme catalysis by heme oxygenases, has been shown to provide protection against ischemia/reperfusion (I/R) injury. We examined the cytoprotective effect of CO at a low concentration on cold I/R injury of transplanted lung grafts. Orthotopic left lung transplantation was performed in syngenic Lewis to Lewis rat combination. Grafts were preserved in University...
Background. Pyrrolidine dithiocarbamate (PDTC) represents a class of antioxidants and is a potent inducer of the heme oxygenase-1 (HO-1) gene and an inhibitor of nuclear factor-κB (NF-κB). We examined the impact of PDTC preconditioning against cold ischemia and reperfusion injury in the rat liver. Methods. Lewis rats were treated subcutaneously with saline or PDTC solution 24 hours before harvesting...
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