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Chemical investigation of the soft coral Lobophytum durum resulted in the isolation of seven new cembranolides, durumolides F–L (1–7), as well as one previously characterized cembranolides, sinularolide D (8). The molecular structures of these isolated metabolites were determined mainly through NMR techniques and HRESIMS analysis. Moreover, the absolute configurations of 1 and 5 were established by...
Chemical investigations on the acetone extract of the soft coral Lobophytum durum have afforded five new cembranoids with a trans-fused α-methylene-γ-lactone, durumolides A–E (1, 6, and 8–10), and five previously characterized cembrane-based diterpenoids (2–5 and 7). The structures of the isolated metabolites were elucidated through extensive spectroscopic analyses, while the relative stereochemistry...
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