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Selective trapping of nanoscale bioparticles (size <100 nm) is significant for the separation and high‐sensitivity detection of biomarkers. Dielectrophoresis is capable of highly selective trapping of bioparticles based on their characteristic frequency response. However, the trapping forces fall steeply with particle size, especially within physiological media of high‐conductivity where the trapping...
We describe a methodology to steeply enhance streptavidin protein preconcentration within physiological media over that achieved by negative dielectrophoresis (NDEP) through utilizing a DC offset to the AC field at nanoscale constriction gap devices. Within devices containing approximately 50‐nm constriction gaps, we find that the addition of a critical DC field offset (1.5 V/cm) to the NDEP condition...
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