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The aim of the present study was to compare the effects of genetic mPGES-1 loss and COX-2 inhibition on myocardial damage after coronary occlusion. mPGES-1 −/− mice and their wild-type littermates were injected with vehicle or COX-2 inhibitor (celecoxib), and 30min later the left coronary artery was surgically occluded. At 24h, myocardial infarct (MI) volume was measured histologically. Post-MI...
The goal of the present study was to assess how genetic loss of microsomal prostaglandin E 2 synthase-1 (mPGES-1) affects acute cardiac ischemic damage after coronary occlusion in mice. Wild type (WT), heterozygous (mPGES-1 +/− ), and homozygous (mPGES-1 −/− ) knockout mice were subjected to left coronary artery occlusion. At 24h, myocardial infarct (MI) volume was measured...
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