Search results for: Jun Lei

Items from 1 to 20 out of 273 results

article

Myeloperoxidase‐Sensitive Magnetic Resonance Imaging Assesses Inflammatory Activation State in Experimental Mouse Acute Gout

Chunrong Zhu, Yunhe Li, Qiao Deng, Xinxin Liu, more

Journal of Magnetic Resonance Imaging > 58 > 6 > 1714 - 1722

Background A novel myeloperoxidase‐activatable manganese‐based (MPO‐Mn) MRI probe may enable the activation state of inflammatory foci to be detected and monitored noninvasively. Purpose To evaluate the inflammatory response in a mouse model of acute gout using MPO as an imaging biomarker and a potential therapeutic target. Study Type Prospective. Animal Model A total of 40 male Swiss mice...

article

Frequency‐domain fundamental solutions and boundary element method for consistent couple stress elastodynamic problems

Jun Lei, Caixia Shao, Chuanzeng Zhang

International Journal for Numerical Methods in Engineering > 124 > 22 > 4992 - 5019

In this article, the elastodynamic problems are investigated within the framework of a consistent couple‐stress theory (CCST). The basic equations for the CCST elastodynamic problems are derived at first. These dynamic formulas are then analyzed in the frequency domain by the Fourier transform. The frequency‐domain fundamental solutions to the transformed elastodynamic problems are subsequently derived...

article

Miniaturization of ultra‐wideband Vivaldi antenna by utilizing double‐layer structure with slots

Wanli Li, Jun Lei, Weiwen Li

Microwave and Optical Technology Letters > 65 > 11 > 3004 - 3008

In a Vivaldi antenna, a symmetrical double‐sided structure is introduced to reduce the lower‐side frequency. Multiple transverse and longitudinal slots loaded into the redundant conductor layer of the Vivaldi structure can stimulate resonant modes at the higher frequency end, further broadening the antenna bandwidth towards high frequencies. Meanwhile, impedance matching slots are introduced into...

article

Near‐infrared (NIR) imaging with indocyanine green (ICG) may assist in intraoperative decision making and improving surgical margin in bone and soft tissue tumor surgery

Huayi Huang, Siyuan He, Renxiong Wei, Xiaobin Zhu, more

Journal of Surgical Oncology > 128 > 4 > 612 - 627

Background and Objectives Negative surgical margins are significant in improving patient outcomes. However, surgeons can only rely on visual and tactile information to identify tumor margins intraoperatively. We hypothesized that intraoperative fluorescence imaging with indocyanine green (ICG) could serve as an assistive technology to evaluate surgical margins and guide surgery in bone and soft tissue...

article

Use of the GRADE system in systematic reviews

Quan Shen, Binglu Wang, Jun Lei

BJOG: An International Journal of Obstetrics & Gynaecology > 130 > 9 > 1147 - 1148

article

Anlotinib improves bile duct ligature‐induced liver fibrosis in rats via antiangiogenesis regulated by VEGFR2/mTOR pathway

Jun Lei, Qing Li, Hongyan Xu, Ming Luo, more

Drug Development Research > 84 > 2 > 143 - 155

Cholestasis is a main clinical feature of biliary atresia (BA), which leads to liver fibrosis (LF). The focus of BA treatment is preventing and slowing the progress of LF. This study reports the improvement effect of anlotinib on common bile duct ligature (BDL)‐induced LF in young rats. The BDL young rats were treated with anlotinib and the serum levels of aspartate aminotransferase, alanine aminotransferase,...

article

Sex‐specific differences in T‐cell immune dysregulation and aberrant response to inflammatory stimuli in offspring exposed to maternal chronic inflammation

Jin Liu, Yang Liu, Gregory Kirschen, Anguo Liu, more

American Journal of Reproductive Immunology > 89 > 3 > n/a - n/a

Problems Maternal chronic inflammation (MI) can adversely affect offspring's immune development resulting in dysregulation of splenic T cells. Interleukin 1 beta (IL‐1β) contributes to mediating inflammation in the placenta to induce fetal toxicity and cause long‐term postnatal sequelae. In this study, we investigated how MI affects the T‐cell immune development from the fetal to the neonatal period...

article

Cognitive behavioural therapy for women with infertility: A systematic review and meta‐analysis

Guangpeng Wang, Xueyan Liu, Jun Lei

Clinical Psychology & Psychotherapy > 30 > 1 > 38 - 53

Cognitive behavioural therapy (CBT) has been used for women with infertility. However, the efficacy of CBT among the infertile female population remains inconclusive. We performed a systematic literature search using the Cochrane Library, MEDLINE (OVID), EMBASE (OVID), CINAHL, PsycINFO (OVID), Web of Science, and ProQuest databases from the inception to May 2022. The Cochrane risk of bias tool for...

article

Spherical boron nitride/silicone rubber composite with high isotropic thermal conductivity via pre‐constructing thermally conductive networks

Yu‐Fan Hu, Xue‐Jun Zhou, Shi‐Hao Ni, Feng‐Yang Wu, more

Journal of Applied Polymer Science > 139 > 38 > n/a - n/a

Thermal interface material (TIM) is crucial for electronic devices to dissipate heat, but the high interface thermal resistance between polymer matrix and filler is a major problem affecting its thermal conductivity (TC). In this study, we prebuilt excellent thermally conductive pathway of isotropic spherical boron nitride (sBN) using a facile method, that is, pressing fillers, to decrease the interface...

article

Ground state solutions for a Schrödinger–Poisson–Slater‐type equation with critical growth

Jiafeng Zhang, Chunyu Lei, Jun Lei

Mathematical Methods in the Applied Sciences > 45 > 12 > 7443 - 7450

We study the existence of ground state solutions of a Schrödinger–Poisson–Slater‐type equation with critical growth. By using the Nehari–Pohozaev manifold, we obtain the existence of ground state solutions of this system.

article

Activating receptor KIR2DS2 bound to HLA‐C1 reveals the novel recognition features of activating receptor

Yi Yang, Hua Bai, Yankang Wu, Peng Chen, more

Immunology > 165 > 3 > 341 - 354

Killer cell immunoglobulin‐like receptors (KIRs) are important receptors for regulating the killing of virus‐infected or cancer cells of natural killer (NK) cells. KIR2DS2 can recognize peptides derived from hepatitis C virus (HCV) or global flaviviruses (such as dengue and Zika) presented by HLA‐C*0102 to activate NK cells, and has shown promising results when used for cancer immunotherapy. Here,...

article

Enhancing thermal conductivity of silicone rubber via constructing hybrid spherical boron nitride thermal network

Xuejun Zhou, Jiyou Zong, Jun Lei, Zhongming Li

Journal of Applied Polymer Science > 139 > 15 > n/a - n/a

In this work, a series of spherical boron nitride/silicone rubber (sBN/SR) composites were prepared, and the influence of different shapes and sizes of BN on the thermal conductivities of the composites was investigated. Additionally, hybrid spherical boron nitride/silicon rubber (hybrid sBN/SR) composites were fabricated by synchronously incorporating two kinds of sBN particles into SR to perfect...

article

Melatonin for prevention of fetal lung injury associated with intrauterine inflammation and for improvement of lung maturation

Ji Yeon Lee, Quan Na, Na E. Shin, Ha Eun Shin, more

Journal of Pineal Research > 69 > 3 > n/a - n/a

Inflammation is associated with injury to immature lungs, and melatonin administration to preterm newborns with acute respiratory distress improves pulmonary outcomes. We hypothesized that maternally administered melatonin may reduce inflammation, oxidative stress, and structural injury in fetal lung and help fetal lung maturation in a mouse model of intrauterine inflammation (IUI). Mice were randomized...

article

The effect of intrauterine inflammation on mTOR signaling in mouse fetal brain

Jie Dong, Jun Lei, Nada A. Elsayed, Ji Yeon Lee, more

Developmental Neurobiology > 80 > 5-6 > 149 - 159

Fetuses exposed to an inflammatory environment are predisposed to long‐term adverse neurological outcomes. However, the mechanism by which intrauterine inflammation (IUI) is responsible for abnormal fetal brain development is not fully understood. The mechanistic target of rapamycin (mTOR) signaling pathway is closely associated with fetal brain development. We hypothesized that mTOR signaling might...

article

Effects of Andersson lesion treatment in ankylosing spondylitis: A medical record review study focused on medium‐ to long‐term outcomes

Minhao Wu, Feifei Yan, Ansong Ping, Jun Lei

International Journal of Rheumatic Diseases > 23 > 6 > 753 - 762

The present study aimed to evaluate the clinical efficacy of Andersson lesion (AL) treatments and prognostic factors using medium‐ to long‐term follow‐up data and discuss the clinical characteristics and treatment of AL. Forty‐eight consecutive AL cases at our center from June 2011 to March 2018 were retrospectively analyzed, including 13 cases treated conservatively and 35 treated surgically. Epidemiological...

article

Dose‐dependent structural and immunological changes in the placenta and fetal brain in response to systemic inflammation during pregnancy

Anna Chudnovets, Jun Lei, Quan Na, Jie Dong, more

American Journal of Reproductive Immunology > 84 > 1 > n/a - n/a

Problem Systemic maternal inflammation is associated with adverse neonatal sequelae. We tested the hypothesis that IL‐1β is a key inflammatory regulator of adverse pregnancy outcomes. Method of study Pregnant mice were treated with intraperitoneal injections of IL‐1β (0, 0.1, 0.5, or 1 μg) from embryonic day (E)14 to E17. Placenta and fetal brains were harvested and analyzed for morphologic changes...

article

Combined effects of avasimibe immunotherapy, doxorubicin chemotherapy, and metal–organic frameworks nanoparticles on breast cancer

Jun Lei, Hongjian Wang, Daoming Zhu, Yibin Wan, more

Journal of Cellular Physiology > 235 > 5 > 4814 - 4823

CD8⁺ T cells play a vital role in cancer immunotherapy and can be shaped by metabolism. Avasimibe is an acyl coenzyme A‐cholesterol acyltransferase (ACAT) inhibitor, which has been clinically verified safe in other phase Ⅲ clinical trials. It can potentiate the killing function of CD8⁺ T cells by modulating cholesterol metabolism. Doxorubicin (DOX) is an anticancer drug widely used in many cancers...

article

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

Min-hao Wu, Ling-fei Xiao, Huo-wen Liu, Zhi-qiang Yang, more

Cancer Imaging > 2019 > 19 > 1 > 1-12

Objective The present study aimed to evaluate the diagnostic performance and safety of PET/CT-guided percutaneous core bone biopsy and to compare the PET/CT-guided method to conventional CT-guided percutaneous core biopsies to diagnose Chinese patients with bone tumors and tumor-like lesions. Methods Data for 97 patients with bone tumors and tumor-like lesions diagnosed by percutaneous core bone...

article

Study on cyanidin metabolism in petals of pink-flowered strawberry based on transcriptome sequencing and metabolite analysis

Li Xue, Jian Wang, Jun Zhao, Yang Zheng, more

BMC Plant Biology > 2019 > 19 > 1 > 1-16

Background Pink-flowered strawberry is a promising new ornamental flower derived from intergeneric hybridization (Fragaria × Potentilla) with bright color, a prolonged flowering period and edible fruits. Its flower color ranges from light pink to red. Pigment compounds accumulated in its fruits were the same as in cultivated strawberry fruits, but different from that in its flowers. However, the transcriptional...

article

Structural system identification by measurement error‐minimizing observability method

Jun Lei, Jose Antonio Lozano‐Galant, Dong Xu, Jose Turmo

Structural Control and Health Monitoring > 26 > 10 > n/a - n/a

This paper proposes a method for the finite element model updating using static load tests under the framework of observability analysis. Previous works included measurement errors in the coefficient matrix of the observability equations. This impeded the obtainment of accurate estimations. To deal with this issue, the proposed method relocates the errors and incorporates an optimization procedure...

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INFONA - science communication portal

Search results for: Jun Lei

Myeloperoxidase‐Sensitive Magnetic Resonance Imaging Assesses Inflammatory Activation State in Experimental Mouse Acute Gout

Frequency‐domain fundamental solutions and boundary element method for consistent couple stress elastodynamic problems

Miniaturization of ultra‐wideband Vivaldi antenna by utilizing double‐layer structure with slots

Near‐infrared (NIR) imaging with indocyanine green (ICG) may assist in intraoperative decision making and improving surgical margin in bone and soft tissue tumor surgery

Use of the GRADE system in systematic reviews

Anlotinib improves bile duct ligature‐induced liver fibrosis in rats via antiangiogenesis regulated by VEGFR2/mTOR pathway

Sex‐specific differences in T‐cell immune dysregulation and aberrant response to inflammatory stimuli in offspring exposed to maternal chronic inflammation

Cognitive behavioural therapy for women with infertility: A systematic review and meta‐analysis

Spherical boron nitride/silicone rubber composite with high isotropic thermal conductivity via pre‐constructing thermally conductive networks

Ground state solutions for a Schrödinger–Poisson–Slater‐type equation with critical growth

Activating receptor KIR2DS2 bound to HLA‐C1 reveals the novel recognition features of activating receptor

Enhancing thermal conductivity of silicone rubber via constructing hybrid spherical boron nitride thermal network

Melatonin for prevention of fetal lung injury associated with intrauterine inflammation and for improvement of lung maturation

The effect of intrauterine inflammation on mTOR signaling in mouse fetal brain

Effects of Andersson lesion treatment in ankylosing spondylitis: A medical record review study focused on medium‐ to long‐term outcomes

Dose‐dependent structural and immunological changes in the placenta and fetal brain in response to systemic inflammation during pregnancy

Combined effects of avasimibe immunotherapy, doxorubicin chemotherapy, and metal–organic frameworks nanoparticles on breast cancer

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

Study on cyanidin metabolism in petals of pink-flowered strawberry based on transcriptome sequencing and metabolite analysis

Structural system identification by measurement error‐minimizing observability method

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