Search results for: Li Hou

Items from 1 to 20 out of 246 results

article

Dinuclear Metal-Mediated Guanine–Uracil Base Pairs: Theoretical Studies of GUM₂²⁺ (M = Cu, Ag, and Au) Ions

Guo-Jin Cao, Hai-Li Hou

Journal of Cluster Science > 2019 > 30 > 2 > 439-448

Dinuclear metal-mediated hetero base pairs with the d¹⁰–d¹⁰ closed-shell interactions have significant stability. It is interesting to identify whether coinage metal-mediated Wobble base pairs are also stable. Geometric and electronic structures of the lowest-lying isomers of GUM₂²⁺ (G = guanine, U = uracil, M = Cu, Ag, and Au) cluster ions were investigated with density functional theory. In the...

article

A Novel Thermal Stable Carbonyl Reductase from Bacillus cereus by Gene Mining as Biocatalyst for β-Carbonyl Ester Asymmetric Reduction Reaction

Yan-Li Qin, Tao Ruan, He-Shuai Hou, Ya-Li Hou, more

Catalysis Letters > 2019 > 149 > 2 > 610-618

Carbonyl reductase, as biocatalyst, is very important to chiral alcohols production through asymmetric reduction of carbonyl compound. A novel thermal stable carbonyl reductase from Bacillus cereus (BcCR) dependant on NADPH was obtained through a new genome mining strategy proposed in this work. By analyzing its amino acid sequence and structure, the BcCR should be a thermal stability and wide pH...

article

A Noble‐Metal‐Free Metal–Organic Framework (MOF) Catalyst for the Highly Efficient Conversion of CO₂ with Propargylic Alcohols

Sheng‐Li Hou, Jie Dong, Xiao‐Lei Jiang, Zhuo‐Hao Jiao, more

Angewandte Chemie International Edition > 58 > 2 > 577 - 581

Cyclization of propargylic alcohols with CO₂ is an important reaction in industry, and noble‐metal catalysts are often employed to ensure the high product yields under environmentally friendly conditions. Herein a porous noble‐metal‐free framework 1 with large 1D channels of 1.66 nm diameter was synthesized for this reaction. Compound 1 exhibits excellent acid/base stability, and is even stable in...

article

A Noble‐Metal‐Free Metal–Organic Framework (MOF) Catalyst for the Highly Efficient Conversion of CO₂ with Propargylic Alcohols

Sheng‐Li Hou, Jie Dong, Xiao‐Lei Jiang, Zhuo‐Hao Jiao, more

Angewandte Chemie > 131 > 2 > 587 - 591

article

Deformylated Gramicidin A and Its Derivatives Showing High Antimicrobial Activity and Low Hemolytic Toxicity

Wei‐Wei Haoyang, Min Zhang, Jun‐Li Hou

Chinese Journal of Chemistry > 37 > 1 > 25 - 29

Gramicidin A is a natural peptide, which shows high antimicrobial activity to Gram‐positive bacteria. However, the hemolytic toxicity prevents its therapeutic usage. We demonstrated that by simply removing the formyl group at the N terminus, the hemolytic toxicity of the peptide could be obviously decreased. The deformylated gramicidin A (1) could efficiently insert into the lipid bilayer to form...

article

Cover Picture: Deformylated Gramicidin A and Its Derivatives Showing High Antimicrobial Activity and Low Hemolytic Toxicity (Chin. J. Chem. 1/2019)

Wei‐Wei Haoyang, Min Zhang, Jun‐Li Hou

Chinese Journal of Chemistry > 37 > 1 > 1 - 1

The cover picture shows A new strategy for preparing antimicrobial peptides from the natural occurring peptide gramicidin A has been developed by simply removing its N‐terminal formyl group and decoration at the terminal NH2 group. The peptides are able to selectively insert into Gram‐positive bacterial membrane to form transmembrane channels but not that of erythrocyte membrane, which leads to their...

article

Mining and standardizing chinese consumer health terms

Li Hou, Hongyu Kang, Yan Liu, Luqi Li, more

BMC Medical Informatics and Decision Making > 2018 > 18 > 5 > 107-117

Background Health professionals and consumers use different terms to express medical events or concerns, which makes the communication barriers between the professionals and consumers. This may lead to bias in the diagnosis or treatment due to the misunderstanding or incomplete understanding. To solve the issue, a consumer health vocabulary was developed to map the consumer-used health terms to professional-used...

article

Preliminary exploration of survival analysis using the OHDSI common data model: a case study of intrahepatic cholangiocarcinoma

Na Hong, Ning Zhang, Huawei Wu, Shanshan Lu, more

BMC Medical Informatics and Decision Making > 2018 > 18 > 5 > 81-88

Background Data heterogeneity is a common phenomenon related to the secondary use of electronic health records (EHR) data from different sources. The Observational Health Data Sciences and Informatics (OHDSI) Common Data Model (CDM) organizes healthcare data into standard data structures using concepts that are explicitly and formally specified through standard vocabularies, thereby facilitating large-scale...

article

CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust

Dafeng Chen, Ji-Xin Tang, Beibei Li, Li Hou, more

BMC Biotechnology > 2018 > 18 > 1 > 1-9

Background The CRISPR/Cas9 system has been widely used to generate gene knockout/knockin models by inducing frameshift mutants in cell lines and organisms. Several recent studies have reported that such mutants can lead to in-frame exon skipping in cell lines. However, there was little research about post-transcriptional effect of CRISPR-mediated gene editing in vivo. Results We showed that frameshift...

article

RNA-seq analysis of gene expression changes during pupariation in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)

Er-Hu Chen, Qiu-Li Hou, Wei Dou, Dan-Dan Wei, more

BMC Genomics > 2018 > 19 > 1 > 1-16

Background The oriental fruit fly, Bactrocera dorsalis (Hendel) has been considered to be one of the most important agricultural pest around the world. As a holometabolous insect, larvae must go through a metamorphosis process with dramatic morphological and structural changes to complete their development. To better understand the molecular mechanisms of these changes, RNA-seq of B. dorsalis from...

article

Nitrogen Codoped Unique Carbon with 0.4 nm Ultra‐Micropores for Ultrahigh Areal Capacitance Supercapacitors

Junshuang Zhou, Li Hou, Sunrui Luan, Jinlong Zhu, more

Small > 14 > 36 > n/a - n/a

A full understanding of ion transport in porous carbon electrodes is essential for achieving effective energy storage in their applications as electrochemical supercapacitors. It is generally accepted that pores in the size range below 0.5 nm are inaccessible to electrolyte ions and lower the capacitance of carbon materials. Here, nitrogen‐doped carbon with ultra‐micropores smaller than 0.4 nm with...

article

Functional analysis of the mitochondrial alternative oxidase gene (aox1) from Aspergillus niger CGMCC 10142 and its effects on citric acid production

Li Hou, Ling Liu, Hongfei Zhang, Lin Zhang, more

Applied Microbiology and Biotechnology > 2018 > 102 > 18 > 7981-7995

In this work, we constructed the aox1 disruption strains 3–4 and 4–10, as well as the aox1 overexpression strains 72 and 102 in Aspergillus niger. The energy metabolism, EMP, TCA pathways, and flux were investigated for the citric acid (CA) overproduction via the aox1 overexpression among them. As expected, the overexpression of the aox1 gene enabled a higher growth rate than that of the rate of its...

article

Quantifying the indirect effects of nitrogen deposition on grassland litter chemical traits

Shuang-Li Hou, Grégoire T. Freschet, Jun-Jie Yang, Yun-Hai Zhang, more

Biogeochemistry > 2018 > 139 > 3 > 261-273

Litter chemical traits are one of the dominant controls on litter decomposition. Increasing atmospheric nitrogen (N) deposition is expected to alter litter chemical traits at the community level in both direct (altering intraspecific chemistry) and indirect ways (changing species abundance and composition). Compared to intraspecific changes, the role of changes in species composition in driving the...

article

HLA‐DRB109:01* allele is associated with anti‐E immunization in a Chinese population

Li Tian, Li Hou, Lixin Wang, Hong Xu, more

Transfusion > 58 > 6 > 1536 - 1539

BACKGROUND Anti‐E is the most common and important RBC alloantibody in the Chinese population. Several studies have demonstrated that the production of specific RBC alloantibodies is associated with HLA‐DRB1 polymorphisms. Considering that the Chinese population has its own unique characteristics of HLA‐DRB1 polymorphisms, we investigate whether specific HLA‐DRB1 alleles are associated with E immunization...

article

Tyrosine hydroxylase coordinates larval–pupal tanning and immunity in oriental fruit fly (Bactrocera dorsalis)

Er‐Hu Chen, Qiu‐Li Hou, Dan‐Dan Wei, Wei Dou, more

Pest Management Science > 74 > 3 > 569 - 578

BACKGROUND The oriental fruit fly Bactrocera dorsalis (Hendel), a notorious world pest infesting fruits and vegetables, has evolved a high level of resistance to many commonly used insecticides. In this study, we investigate whether tyrosine hydroxylase (TH) that is required for cuticle tanning (sclerotization and pigmentation) in many insects, could be a potential target in controlling B. dorsalis...

article

Intraspecific variation drives community-level stoichiometric responses to nitrogen and water enrichment in a temperate steppe

Xiao-Tao Lü, Yan-Yu Hu, Hai-Yang Zhang, Hai-Wei Wei, more

Plant and Soil > 2018 > 423 > 1-2 > 307-315

Aims The responses of functional structures in plant communities to global change drivers is predicted to be driven by both species turnover and intraspecific trait variability (ITV). However, the relative importance of those two drivers is not well-known, which retards our ability to predict the functional changes of plant community under global change scenarios. We hypothesized that ITV rather than...

article

Adipokinetic hormone receptor gene identification and its role in triacylglycerol mobilization and sexual behavior in the oriental fruit fly (Bactrocera dorsalis)

Qiu-Li Hou, Er-Hu Chen, Hong-Bo Jiang, Dan-Dan Wei, more

Insect Biochemistry and Molecular Biology > 2017 > 90 > C > 1-13

Energy homeostasis requires continuous compensation for fluctuations in energy expenditure and availability of food resources. In insects, energy mobilization is under control of the adipokinetic hormone (AKH) where it is regulating the nutritional status by supporting the mobilization of lipids. In this study, we characterized the gene coding for the AKH receptor (AKHR) and investigated its function...

article

Consistent responses of litter stoichiometry to N addition across different biological organization levels in a semi-arid grassland

Shuang-Li Hou, Jiang-Xia Yin, Jun-Jie Yang, Hai-Wei Wei, more

Plant and Soil > 2017 > 421 > 1-2 > 191-202

Aims Changes in litter chemistry and stoichiometry following N enrichment have important consequences on litter decomposition and plant-mediated nutrient cycling. Our knowledge about the responses of litter stoichiometry at different biological organization levels to N enrichment remains poorly understood. Moreover, whether the impacts of N enrichment on stoichiometric ratios in litter would depend...

article

Effects of Compound Zhebei Granule (复方浙贝颗粒) Combined with Doxorubicin on Expression of Specific Surface Antigens in Mice with Transplanted KG-1a Cells

Yu Zhang, Li Hou, Xin-yi Chen

Chinese Journal of Integrative Medicine > 2018 > 24 > 3 > 213-217

Objective To investigate the effects of Compound Zhebei Granule (复方浙贝颗粒, CZG) combined with doxorubicin hydrochloride (adriamycin, ADM) on specific surface antigens in mice with KG-1a transplanted cells. Methods A subcutaneous tumor xenograft model was established by injection of the acute myeloid leukemia cell line KG-1a into the axillary flfl anks of BALB/c-nude mice. Twenty-four tumor bearing...

chapter

Occlusion localization based on convolutional neural networks

Ya-Li Hou, Jinzhang Peng, Xiaoli Hao, Yan Shen, more

2017 IEEE International Conference on Signal Processing, Communications and Computing (ICSPCC) > 1 - 5

2017 IEEE International Conference on Signal Processing, Communications and Computing (ICSPCC)

In most convolutional neural networks (CNNs), the output is a single classification result by combining all the neuron activations in the last layer. As we know, local connectivity is an important characteristic of CNNs. Each neuron in the network corresponds to a local region in the original image. Hence, it is possible to simultaneously obtain local visibility of a target object by analyzing neuron...

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INFONA - science communication portal

Search results for: Li Hou

Dinuclear Metal-Mediated Guanine–Uracil Base Pairs: Theoretical Studies of GUM₂²⁺ (M = Cu, Ag, and Au) Ions

A Novel Thermal Stable Carbonyl Reductase from Bacillus cereus by Gene Mining as Biocatalyst for β-Carbonyl Ester Asymmetric Reduction Reaction

A Noble‐Metal‐Free Metal–Organic Framework (MOF) Catalyst for the Highly Efficient Conversion of CO₂ with Propargylic Alcohols

A Noble‐Metal‐Free Metal–Organic Framework (MOF) Catalyst for the Highly Efficient Conversion of CO₂ with Propargylic Alcohols

Deformylated Gramicidin A and Its Derivatives Showing High Antimicrobial Activity and Low Hemolytic Toxicity

Cover Picture: Deformylated Gramicidin A and Its Derivatives Showing High Antimicrobial Activity and Low Hemolytic Toxicity (Chin. J. Chem. 1/2019)

Mining and standardizing chinese consumer health terms

Preliminary exploration of survival analysis using the OHDSI common data model: a case study of intrahepatic cholangiocarcinoma

CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust

RNA-seq analysis of gene expression changes during pupariation in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)

Nitrogen Codoped Unique Carbon with 0.4 nm Ultra‐Micropores for Ultrahigh Areal Capacitance Supercapacitors

Functional analysis of the mitochondrial alternative oxidase gene (aox1) from Aspergillus niger CGMCC 10142 and its effects on citric acid production

Quantifying the indirect effects of nitrogen deposition on grassland litter chemical traits

HLA‐DRB109:01* allele is associated with anti‐E immunization in a Chinese population

Tyrosine hydroxylase coordinates larval–pupal tanning and immunity in oriental fruit fly (Bactrocera dorsalis)

Intraspecific variation drives community-level stoichiometric responses to nitrogen and water enrichment in a temperate steppe

Adipokinetic hormone receptor gene identification and its role in triacylglycerol mobilization and sexual behavior in the oriental fruit fly (Bactrocera dorsalis)

Consistent responses of litter stoichiometry to N addition across different biological organization levels in a semi-arid grassland

Effects of Compound Zhebei Granule (复方浙贝颗粒) Combined with Doxorubicin on Expression of Specific Surface Antigens in Mice with Transplanted KG-1a Cells

Occlusion localization based on convolutional neural networks

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