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Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is associated with atherosclerosis. Subclinical hypothyroidism (sHT) is associated with the increased prevalence of atherosclerotic lesions and cardiovascular events. Therefore, we hypothesized that circulating TRAIL levels are associated with endothelial dysfunction in sHT patients. Two hundred and four patients with newly...
Polymorphisms of the NR3C1 (glucocorticoid receptor) gene have been reported to be associated with altered glucocorticoids sensitivity and changes in body composition and metabolic parameters. This study explored the relationship between single nucleotide polymorphisms (SNPs) of the NR3C1 gene and metabolic syndrome (MetS) in a Chinese population. Fourteen tag-SNPs and five functionally important...
Although IGF-I was known to stimulate the growth of pancreatic islet cells from early in vitro experiments and in vivo reports on rodents, recent gene targeting experiments have indicated that IGF-I and its receptor do not play a major role in normal islet cell growth. In our previous reports, liver- or pancreatic-specific IGF-I deficiency caused no decrease in β-cell mass; a general and β-cell-enriched...
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