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Des études antérieures ont montré l’importance d’un cofacteur de transcription nommé HMGA1 dans la régulation de l’expression du récepteur à l’insuline, INSR. En effet, les souris Hmga1–/– développent une insulino-résistance associée à un phénotype proche du diabète de type 2 humain (DT2). Ces résultats sont également observés chez des patients porteurs de délétions dans la région 3’UTR d’HMGA1. La...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.