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This paper presents a microfluidic system enabling continuous characterization of specific membrane capacitance (Cspecific membrane) and cytoplasm conductivity (σcytoplasm) of single biological cells. In this study, cells were aspirated through a constriction channel while cell elongations and impedance profiles at 1 kHz and 100 kHz were measured simultaneously using microscopy imaging and a lock-in...
Fast axonal conduction of action potentials in mammals relies on myelin insulation. Demyelination can cause slowed, blocked, desynchronized, or paradoxically excessive spiking that underlies the symptoms observed in demyelination diseases. Feedback control via functional electrical stimulation (FES) seems to be a promising treatment modality in such diseases. However, there are challenges to implementing...
Nerve cells communicate by generating and transmitting action potentials. Annihilation of neural oscillation by functional electrical stimulation is a promising treatment modality in neural diseases. In this paper, a robust adaptive fuzzy tracking control is proposed for stochastic Hodgkin-Huxley (HH) neuron systems to generate a desired reference response in spite of environmental noises, uncertain...
We study the nonlinear response of the HodgkinHuxley model without external periodic signal to Gaussian white noise (GWN) and Ornstein-Uhlenbeck noise (OUN) as synaptic current respectively near the saddle-node bifurcation of limit cycles. The coherence of the system, estimated from the Coefficient of Variation of interspike interval of membrane potentials and spike trains, is minimal at certain noise...
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