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Normal cellular homeostasis employs a delicate balance between pro-apoptotic (cell death) and anti-apoptotic (growth-stimulatory) forces. Unrestricted/unregulated cell growth, which occurs in neoplasia frequently, accompanies an imbalance in these forces and frequently the apoptotic pathways are disrupted leading to increased metastatic spread, resistance to chemotherapy and radiotherapy. Pro-apoptotic...
Purpose Luteinizing hormone receptor (LHR) is found in abundance on human ovarian, breast, endometrial and prostate carcinomas but at only low levels on non-gonadal tissues. To selectively kill LHR-expressing tumors, granzyme B (GrB) was linked to a protein in which both chains of human chorionic gonadotropin were yoked together (YCG). Methods GrB-YCG was expressed and secreted from insect Sf9 cells...
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