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Taking advantage of the character of Au nanorods (NRs) to absorb NIR light, a NIR‐responsive oligonucleotide‐gated ensemble is developed to perform intracellular drug delivery. Using an oligonucleotide bio‐gate enables siRNA release into cells for translational regulation as well as cytotoxicity in anti‐cancer drug delivery.
NIR‐responsive oligonucleotide‐gated ensembles are developed on page 3309 by F.‐Y. Cheng, C.‐S. Yeh, and co‐workers for intracellular drug delivery. Taking advantage of the NIR‐absorbing character of gold nanorods, a CW NIR diode laser is employed to control cargo and drug release through the thermal dehybridization of duplex oligonucleotides. This design has great therapeutic potential, with capabilities...
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