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Inducing apoptosis is a promising therapeutic approach to overcome cancer. Here we described that a novel synthesized compound, 3-amino-N-(4-chlorobenzyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide (SKLB703), exhibits antitumor activity via inducing apoptosis both in vitro and in vivo. Our results showed that SKLB703 inhibited the proliferation of a panel of human cancer cell lines, and...
The epithelial-mesenchymal transition regulator Twist1 has been implicated in tumor invasion, metastasis, and vasculogenic mimicry formation of human hepatocellular carcinoma. However, the relationship between Twist1 expression and endothelium-dependent angiogenesis is not clear. In this study, to investigate the role of Twist1 in hepatocellular carcinoma angiogenesis, we measured the microvessel...
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