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The remnant liver after extended liver resection is susceptible to ischemic injury, resulting in the failure of liver regeneration and liver dysfunction. The present study is aimed to investigate the protective role of the liver epithelial cells (LEC), a liver progenitor cell, on hepatocytes with ischemia in vitro and in vivo.LECs were isolated from rats and cultured under hypoxic conditions (2% O...
Background. The aim of this study was to evaluate the clinicopathologic characteristics of patients with hepatocellular carcinoma (HCC) and bile duct thrombi (BDT). Patients. Seventeen patients with HCC and BDT among 671 patients with HCC who underwent hepatic resection were enrolled in this study. Results. There were no significant differences in the survival rates between patients with and those...
Background: Ischemic preconditioning (IPC) is a promising strategy for conferring ischemic tolerance. We confirmed the acquisition of ischemic tolerance in the liver immediately after IPC and the role of adenosine kinetics in this process. Methods: Male Lewis rats were used. IPC was administered with a 10-minute ischemia followed by a 10-minute reperfusion. Ischemic tolerance was tested with a 45-minute...
Background. Induction of heat shock proteins is thought to have a > cytoprotective effect againstenvironmental stress and to result in a better ischemic tolerance. The protective ability of heat exposure and heat shock protein 72 (HSP 72) induction before warm ischemia caused by Pringle's maneuver was evaluated in rats.Methods. Heat exposed rats (HS) were compared with control animals (C). The...
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