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The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-d-glucopyranoside and 6-deoxy-6-amino-β-d-mannopyranoside scaffolds has been achieved. The inhibitors had IC 50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.
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