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A series of estradiol dimers was synthesized or selected from compounds available in our laboratory and tested for inhibition against steroid sulfatase. Dimers linked by their C17 position, compounds 7 and 8, showed inhibitory potency similar (56% and 54% at 1μM) to that of our best previously reported reversible inhibitor EM-690 (62% at 1μM). Docking experiment seems to indicate that C17–C17 dimers...
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