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Epithelial Ca 2+ channel (ECaC1 and 2 = CAT1) molecules are characterized by properties including inward rectification and Ca 2+ -dependent fast and slow inactivation. To elucidate the electrophysiological differences based on the amino acid residues, we compared human and rodent ECaC1, and ECaC2 alignments, made mutants, and investigated their function in Xenopus and mammalian cells...
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