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Phormidolides B and C are cytotoxic polyketide macrolides isolated from a marine sponge. The marine environment offers an extensive source of new molecular entities produced as chemical defense against pathogens. These compounds have diverse and potent bioactivities and are excellent candidates for the investigation of new molecules with high pharmacological potential. For more information, see the...
New cytotoxic polyketide macrolides named phormidolides B and C were isolated from a marine sponge of the Petrosiidae family collected off the coast of Pemba (Tanzania). The isolation, structure elucidation, and enantioselective synthesis of three diastereomers of the macrocyclic core is described herein. The described synthetic methodology started from 2‐deoxy‐D‐ribose or 2‐deoxy‐L‐ribose and afforded...
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