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Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shown to be an important predisposing factor for atopic dermatitis (AD).To study the role of FLG mutations in IV/AD in Japan.The known filaggrin mutations were studied by genotyping and new mutations identified by DNA sequencing...
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