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Using T cell receptor (TCR) Vβ8.1 transgenic mice, we have developed an in vivo system for the study of peripheral T cell tolerance, in which two distinct mechanisms of peripheral tolerance are observed to act simultaneously during the maintenance phase of the nonresponsive state. These two mechanisms, anergy and suppression, have been studied using the CD4+T cell lineage markers 6C 10 and CD25, which...
Our studies on the immune response to foreign antigens are reviewed as they relate to the mechanisms of peripheral immune tolerance. The activation of suppressor T cells by distinct modes of antigen presentation is discussed. Through the use of mice expressing transgenic T-cell receptors specific for foreign antigens, we have concluded that the separable mechanisms of anergy and active suppression...
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