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Effective vaccines that function through humoral immunity seek to produce high‐affinity antibodies. Our previous research identified the single‐nucleotide polymorphism rs3922G in the 3ʹUTR of CXCR5 as being associated with nonresponsiveness to the hepatitis B vaccine. The differential expression of CXCR5 between the dark zone (DZ) and light zone (LZ) is critical for organizing the functional structure...