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We evaluated the therapeutic potential of a recombinant 61-residue neuregulin-1 (beta2aisoform) receptor-active peptide (rhNRG-1) in multiple animal models of heart disease.Activation of the erbB family of receptor tyrosine kinases by rhNRG-1 could provide a treatment option for heart failure, because neuregulin-stimulated erbB2/erbB4 heterodimerization is not only critical for myocardium formation...
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