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Seven human milks were subjected to an in vitro digestion with pepsin and pancreatin to identify the peptides released from human proteins. On the basis of their sequences, 11 of the 23 peptides were synthesised and their angiotensin converting enzyme (ACE)-inhibitory and antioxidant activities were measured. The β-casein peptides HLPLP and WSVPQPK showed potent ACE-inhibitory and antioxidant activity,...
Several novel peptides with demonstrated antihypertensive activity have been identified in milk fermented with Enterococcus faecalis CECT 5727. Two of the identified peptides, corresponding to β-casein f(133–138) (LHLPLP) and β-casein f(58–76) (LVYPFPGPIPNSLPQNIPP), showed angiotensin converting enzyme-inhibitory (ACEI) activity (IC 50 ) values as low as 5μm. These peptides demonstrated antihypertensive...
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