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Phospholipase C-β (PLC-β) isozymes (EC 3.1.4.11) hydrolyze the membrane phospholipid phosphatidylinositol-4,5-bisphosphate to generate intracellular second messenger signaling molecules inositol-1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) in response to receptor activation and other cellular stimuli. PLCβ1 and PLCβ3 isozymes were previously demonstrated to bind the calcium-sensitive molecule...
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