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Nonylphenol (NP) is a well‐known endocrine disruptor that influences sexual and reproductive development. Here, we investigated whether NP affects immune responses that are associated with tumor initiation and progression. When spleen cells were incubated with lipopolysaccharide (LPS) and concanavalin A in the presence of 10−4 M NP, the proliferation of B and T lymphocytes was reduced compared with...
Nonylphenol (NP) as well‐known “endocrine disrupter” influences sexual and reproductive development. Here, we investigated the effect of NP on M1‐/M2‐type macrophages and their role in lipopolysaccharide (LPS)‐induced sepsis. Polarized macrophages of M1‐ and M2‐types were obtained by the treatment with LPS and interleukin‐4 (IL‐4) to bone marrow‐derived macrophages (BMDM), respectively. Coincubation...
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