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The metabolism of selected substrates by cytochromes P450 (P450) 2B1, 2B4, and 2B6 was compared, and the effects of cytochrome b 5 (b 5 ) on these reactions were assessed. There did not appear to be any trends regarding the effects of b 5 when the metabolism of a given substrate by the different P450 enzymes was compared. The changes in spin states of the P450 enzymes as a...
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