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The effects of increases in intracellular adenosine 3 :5 -cyclic monophosphate (cyclic AMP) on bradykinin (BK)-induced generation of inositol phosphates (IPs) and Ca 2+ mobilization were investigated in canine cultured tracheal smooth muscle cells (TSMCs). Pretreatment of TSMCs with r forskolin or dibutyryl cyclic AMP attenuated BK-stimulated responses. The inhibitory effects of...
Regulation of the increase in inositol 1,4,5-trisphosphate (IP 3 ) production and intracellular Ca 2+ concentration ([Ca 2+ ] i ) by protein kinase C (PKC) was investigated in cultured canine tracheal smooth muscle cells (TSMCs). Stimulation of TSMCs by bradykinin (BK) led to IP 3 formation and caused an initial transient peak followed by a sustained...
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