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Alzheimer’s disease (AD) is associated with plaque deposition in the brain of AD patients. The major component of the aggregate is a 39–42 long peptide termed β-amyloid (Aβ). Except for Aβ, plaques contain several other components which co-precipitate together with Aβ. One such component is the small heat shock protein (sHSP) αB-crystallin. Instead of preventing the cell from the neurotoxicity of...
In this communication, we suggest that transferred residual dipolar couplings (trRDCs) can be employed to restrain the structure of peptide inhibitors transiently binding to β-amyloid fibrils. The effect is based on the spontaneous alignment of amyloid fibrils with the fibril axis parallel to the magnetic field. This alignment is transferred to the transiently binding peptide inhibitor and is reflected...
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