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1,1-Bis(3′-indolyl)methane (DIM) and the 5,5′-dibromo ring substituted DIM (5,5′-diBrDIM) inhibited growth of MCF-7 and MDA-MB-231 breast cancer cells, and IC 50 values were 10–20 and 1–5μM, respectively, in both cell lines. DIM and 5,5′-diBrDIM did not induce p21 or p27 protein levels or alter expression of Sp1 or Sp3 proteins in either cell line. In contrast, 10μM 5,5′-diBrDIM downregulated...
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