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Magainin 2 (MAG2) and PGLa are two related antimicrobial peptides found in the skin of the African frog Xenopus laevis with a pronounced synergistic activity, which act by permeabilizing bacterial membranes. To probe the influence of hydrophobic peptide–lipid and peptide–peptide interactions on the antimicrobial activity and on synergy, the sequence of MAG2 was modified by replacing single amino acids...
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