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STK39 interacts with OXSR1 and phosphorylates the sodium-chloride co-transporter (SLC12A3), which plays a critical role in regulating the salt/water balance and blood pressure. Here we tested whether STK39, OXSR1, and SLC12A3 genetically contribute to hypertension in the Han Chinese population and how the SNP to SNP or SNP to other risk factors interacts in the pathogenesis of hypertension.Eleven...
This paper presents a clustering method based on genetic algorithm (GA) for Wireless Application Protocol (WAP) log. Firstly WAP log files are pre-processed and the behavior features of WAP service users are extracted. Then the similarity matrix is constructed to compute the similarities between the behavior feature vectors of WAP service users. Furthermore, compute near-optimal solutions by mapping...
Nicotine, the chemical compound which causes cigarette addiction, could be responsible for some lung cancers. Evidence for genetic influence on smoking behavior and nicotine dependence has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health. Recently, the locus containing two genes encoding nicotine...
To search polymorphic biallelic markers on human Y chromosome in Chinese Shandong Han population, calculate their allele and haplogroup frequency, and to obtain their population genetic data are reported. Genotyping of 5 biallelic markers on human Y chromosome (M9, M89, M95, M122, M134) were carried out in a sample of 302 unrelated Chinese male individuals living in Shandong using fragment length...
DEC1, also known as SHARP-2 or Stral3, is an important molecule in embryonic differentiation and a bHLH type transcriptional regulator. It has recently been identified to be abundantly expressed in several human tumors and might play an important role in tumor development. But its expression in gastric carcinoma is unknown. In this study we show that DEC1 was frequently expressed in six gastric carcinoma...
AFP-producing gastric carcinoma(APGC) are known to have a poorer prognosis and to show a higher incidence of liver metastasis than ordinary gastric carcinoma. Therefore, surgical resection, chemotherapy or radiotherapy is usually not satisfactory. In recent years, effects of arsenic trioxide (As2O3) on cell proliferation and induced apoptosis of solid tumors have been widely studied, while little...
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